Publications by authors named "L Loube Daniel"
Introduction: Thyroid nodules are infrequent findings in children, though malignancy rates are higher in this population. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) standardizes the reporting of thyroid fine needle aspiration (FNA) specimens and has become a global reference for assessing the risk of malignancy (ROM) of thyroid nodules. The 2023 update includes pediatric-specific risk predictions and management recommendations.
View Article and Find Full Text PDFMRE11 nuclease is a central player in signaling and processing DNA damage, and in resolving stalled replication forks. Here, we describe the identification and characterization of new MRE11 inhibitors MU147 and MU1409. Both compounds inhibit MRE11 nuclease more specifically and effectively than the relatively weak state-of-the-art inhibitor mirin.
View Article and Find Full Text PDFBackground: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive behaviors. Environmental pollutants may contribute to the etiology of ASD, but studies of perfluoroalkyl substances (PFAS) have shown conflicting results.
Objectives: We assessed associations between cord blood concentrations of PFAS with autistic traits at age seven years in a Singaporean birth cohort.
Article Synopsis
- Optimizing oncolytic viruses for cancer treatment involves removing harmful genes and adding new ones to improve their ability to replicate and stimulate immune responses.
- The complex nature of viral genomes and the difficulty of creating modified viruses have slowed progress in developing these therapies.
- Researchers used a novel strategy involving antibiotics, transposon systems, and advanced sequencing to efficiently engineer safer and more effective oncolytic viruses by identifying useful genetic changes.