Publications by authors named "L Losi"
Article Synopsis
- Thymidylate synthase (TS) is important for DNA synthesis and repair, and its overexpression contributes to drug resistance in cancer cells, particularly in ovarian and colon cancers.
- This study found that novel TS dimer disrupters (Ddis) were more effective at killing cancer cells when used alongside inhibitors of drug efflux proteins, which prevent the drugs from leaving the cells.
- The research also utilized a protein transfection agent to enhance the uptake of these Ddis, leading to reduced TS protein levels and disruptions in the cell cycle, indicating potential for improved cancer therapies.
Optimal time to definitive enucleation of large cysts following marsupialization: A single center, retrospective study.
J Stomatol Oral Maxillofac Surg
September 2024
Objectives: Optimal time to enucleation following marsupialization of large odontogenic mandibular cysts is undefined. We aim to assess volume reduction throughout follow-up, to indicate optimal time to enucleation. Secondary objectives include the identification of factors influencing cyst reduction.
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- Coronary artery disease (CAD) is prevalent in patients with aortic valve stenosis (AS), affecting 60%-80% of this population, leading to unclear outcomes post-Transcatheter Aortic Valve Implantation (TAVI).
- The study analyzed 439 patients with severe AS, using Quantitative Flow Ratio (QFR) from coronary angiography to assess long-term clinical outcomes, focusing on all-cause mortality and a combination of cardiovascular events after TAVI.
- Findings indicated that 20.1% of patients had poor QFR values, which were associated with a significantly higher risk of mortality and major adverse cardiovascular events, specifically noting that impaired blood flow in the left anterior descending artery (LAD) linked to
Purpose: The term of placenta accreta spectrum (PAS) disorder includes all grades of abnormal placentation. It is crucial for pathologist provide standardized diagnostic assessment to evaluate the outcome of management strategies. Moreover, a correct and safe diagnosis is useful in the medico-legal field when it becomes difficult for the gynecologist to demonstrate the suitability and legitimacy of demolitive treatment.
View Article and Find Full Text PDFTotal bilateral Limbal Stem Cell Deficiency is a pathologic condition of the ocular surface due to the loss of corneal stem cells. Cultivated oral mucosa epithelial transplantation (COMET) is the only autologous successful treatment for this pathology in clinical application, although abnormal peripheric corneal vascularization often occurs. Properly characterizing the regenerated ocular surface is needed for a reliable follow-up.
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