Publications by authors named "L Losappio"
Article Synopsis
- - The study investigates the link between eosinophilia and ocular vascular issues, highlighting the procoagulant effects of eosinophils, which can lead to various cardiovascular problems and eye conditions.
- - A retrospective, multicenter analysis of 57 patients revealed that the majority experienced eye issues as the first sign of eosinophil-related diseases, with specific conditions like central retinal artery occlusion being common among them.
- - The findings indicate a poor visual prognosis for these patients, with only 10% achieving full recovery, suggesting the need for urgent treatment and further research on eosinophilia's impacts.
Lancet Rheumatol
December 2023
Article Synopsis
- This study evaluated the effectiveness and safety of the IL-5 receptor inhibitor benralizumab for treating patients with eosinophilic granulomatosis with polyangiitis (EGPA) across 28 European centers.
- Out of 121 patients treated, complete responses increased from 12.4% at 3 months to 46.4% at 12 months, while partial responses decreased over the same period.
- Notable improvements were seen in disease activity, as measured by the Birmingham Vasculitis Activity Score (BVAS), and a reduction in various disease manifestations, alongside better lung function.
Int Arch Allergy Immunol
March 2024
Article Synopsis
- * The study involved 214 patients with noted hazelnut allergies, assessing their sensitization to specific hazelnut proteins (Cor a 1, Cor a 8, and Cor a 9) and found that those monosensitized to Cor a 8 had more severe allergic reactions compared to those sensitized to Cor a 1 or both proteins.
- * Results suggest that multiple sensitivities impact the severity of reactions, with patients who are only sensitized to Cor a 8 experiencing more frequent and intense system reactions than those with broader
