Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model.

Neurofibromatosis Type 1 (NF1) is one of the most common genetically inherited disorders that affects 1 in 3000 children annually. Clinical manifestations vary widely but nearly always include the development of cutaneous, plexiform and diffuse neurofibromas that are managed over many years. Recent single-cell transcriptomics profiling efforts of neurofibromas have begun to reveal cell signaling processes.

Epidemiology of road traffic incidents in Peru 1973-2008: incidence, mortality, and fatality.

Background: The epidemiological profile and trends of road traffic injuries (RTIs) in Peru have not been well-defined, though this is a necessary step to address this significant public health problem in Peru. The objective of this study was to determine trends of incidence, mortality, and fatality of RTIs in Peru during 1973-2008, as well as their relationship to population trends such as economic growth.

Methods And Findings: Secondary aggregated databases were used to estimate incidence, mortality and fatality rate ratios (IRRs) of RTIs.

[Morbidity and mortality in low birth weight infants].

The results in morbidity and mortality between 415 newborn infants with birth weight under 2,500 g are presented; the patients with great congenital malformations were not included. The population was divided in three categories 1,500-2,499 g, 1,000-1,499 g and less than 1,000 g and each categorie was divided in small for gestational age (SGE) and appropriate for gestational age (AGE). The mortality rate was very high in the extreme low birth weight.