Publications by authors named "L Lode"
Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix.
View Article and Find Full Text PDFPurpose: Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies. However, the detrimental side effects of treatment make it difficult for many patients to complete the guideline-required treatment. Such non-adherence may jeopardize the lifesaving ability of anti-estrogen therapy.
View Article and Find Full Text PDFBackground: Spigelian hernia is a rare hernia of the abdominal wall. Due to lack of evidence, there is no standard recommendation for surgical technique of Spigelian hernia repair. The aim of this study was to evaluate the outcomes after open and laparoscopic, elective and emergency repair of Spigelian hernias on a nationwide basis.
View Article and Find Full Text PDFArticle Synopsis
- MEN1 is an autosomal dominant disease linked to mutations in the MEN1 tumor suppressor gene, which complicates patient care due to uncertain pathogenicity of gene variants.
- A case study of a 26-year-old male with hyperparathyroidism revealed a MEN1 variant of uncertain significance, which was later classified as pathogenic through functional genetic testing.
- This classification enabled tailored medical management and genetic counseling for the patient and allowed for noninvasive prenatal diagnosis of the variant in future offspring.