Predicting Severe Radiation Pneumonitis in Patients With Locally-Advanced Non-Small-Cell Lung Cancer After Thoracic Radiotherapy: Development and Validation of a Nomogram Based on the Clinical, Hematological, and Dose-Volume Histogram Parameters.

Purpose: This study aimed to investigate the risk factors for severe radiation pneumonitis (RP) after thoracic radiotherapy (RT) in patients with locally advanced non-small cell lung cancer (NSCLC), develop a prediction model to identify high-risk groups, and investigate the impact of severe RP on overall survival (OS).

Methods: We retrospectively collected clinical, dosimetric, and hematological factors of patients with stage III NSCLC receiving thoracic RT without immunotherapy. The primary and secondary end points were severe RP and OS, respectively.

Unveiling the aroma retention secrets in roasted ducks: Structural properties and formation mechanisms of micro-nano particles of aroma-containing compounds.

The study aimed to investigate changes in morphology, structural properties, volatile organic compounds (VOCs), and interbinding mechanisms of the micro-nano particles of aroma-containing compounds (MNPs-ACCs) in roasted ducks subjected to different roasting times (0, 20, 30, 40, 50, 60 min) with varied filtration scales (centrifugation, microfiltration, and ultrafiltration). The presence of MNPs-ACCs in roasted ducks was confirmed by the Tyndall effect, scanning electron microscopy, and electronic nose. These particles showed negative charge, increased size and ζ-potential, and decreased dispersion index with roasting times.

Characterization of quorum quenching enzyme AiiA and its potential role in strawberry preservation.

Microbial spoilage in nutrient-rich strawberries has led to significant food waste and economic loss in the food industry. The quorum-quenching enzyme AiiA is believed to disrupt communication between cells by inactivating AHLs-based quorum sensing signals. Chitosan, a biopolymer derived from chitin, is widely used as a coating film to inhibit bacterial growth and prolong food shelf life.

PAI-1-driven SFRP2 cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy.

The abscopal effect of radioimmunotherapy, wherein tumor shrinkage occurs beyond the irradiated field, is therapeutically promising but clinically rare. The mechanisms underlying this effect remain elusive. Here, in vivo genome-wide CRISPR screening identifies SFRP2 as a potential stromal regulator of the abscopal effect.

Construction of microencapsulated (-)-Epigallocatechin-3-gallate (EGCG) phospholipid-based nanovesicles: Enhancing stability, gastrointestinal resistance and masking bitterness.

Phospholipid-based nanovesicles (PBN) are effective in drug delivery and bitterness masking, but they often lack stability, and traditional emulsion microcapsules fail to mask flavors effectively. This study aimed to develop a phospholipid-based nanovesicle microcapsule (PBN-M) with a dual vesicle-shell structure to encapsulate (-)-epigallocatechin-3-gallate (EGCG), enhancing its stability and bitterness masking. PBN-M was created using an emulsion transfer template method and spray drying.