Publications by authors named "L Liskova"
Article Synopsis
- Scientists are worried about a type of infection that can make people really sick, especially those with weak immune systems.
- They're looking for new ways to treat these infections because some medicines don't work anymore.
- This study created a new way to test these infections on pigs, which helps understand how they develop and how the body heals itself after getting hurt.*
Skin and soft tissue infections (SSTIs) represent a significant healthcare challenge, particularly in the context of increasing antibiotic resistance. This study investigates the efficacy of a novel therapeutic approach combining bacteriophage (phage) therapy with a gum Karaya (GK)-based hydrogel delivery system in a porcine model of deep staphylococcal SSTIs. The study exploits the lytic activity and safety of the Staphylococcus phage 812K1/420 of the Kayvirus genus, which is active against methicillin-resistant Staphylococcus aureus (MRSA).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how Aurora kinase A affects the phosphorylation of CPEB1, which is essential for regulating mRNA translation during the maturation of oocytes in mammals.
- - Researchers inhibited Aurora kinase A using a specific inhibitor, MLN8237, while observing porcine oocytes' meiotic maturation.
- - Results indicate that inhibiting Aurora kinase A does not impact the polyadenylation of cyclin B1 mRNA or its translation, suggesting this kinase is not crucial for CPEB1 activation.
Background: Blood pressure (BP) increases with age and obesity. We have assessed the relative contribution of age and fatness to BP regulation in a healthy population investigated by nurse practitioners.
Material And Methods: Preventive investigation and counseling was offered at the entrance hall of the regional authority´s office in the town of Nitra by 2 nursing specialists who investigated 120 men and 276 women.
Article Synopsis
- Condensins I and II are crucial for chromosome behavior in both mitosis and meiosis, and this study explores their subunits in mammalian oocytes for the first time.
- Through immunoblotting, it was found that while some condensin subunits like SMC2 did not show significant changes during oocyte maturation, others like CAP-D2 and CAP-D3 exhibited multiple isoforms, suggesting post-translational modifications might be at play.
- The research also showed that CAP-H localizes in the cytoplasm and CAP-H2 in the nucleus, highlighting their distinct roles in oocyte maturation using immunofluorescence staining techniques.