Publications by authors named "L Licata"
Article Synopsis
- Uterine lipoleiomyosarcomas (L-LMS) and liposarcomas (LPS) are very rare malignant tumors occurring in the uterus, particularly affecting postmenopausal women, with common symptoms being metrorrhagia and abdominal pain.
- The case discussed involves a patient with L-LMS and pleomorphic LPS, with contrast-enhanced computed tomography (CECT) playing a critical role in diagnosis by distinguishing between the tumor components.
- The essay aims to highlight the importance of CECT imaging in diagnosing these rare tumors and includes a review of existing literature on liposarcomas in the uterine corpus.
Importance: Clinical trials are the path to test and introduce new therapies in the clinic. Trials that are unable to produce results represent inefficiency in the system and may also undermine patient confidence in the new drug development process.
Objectives: To survey the immunotherapy clinical trial landscape of breast cancer between January 2004 and April 2023 and examine what fraction of trials with primary completion date up to November 30, 2022, failed to report outcome, assessing the proportion of trials that yielded positive results and describing trial features associated with these 2 outcomes.
Immunotherapy has revolutionized cancer therapy and now represents a standard of care for many tumor types, including triple-negative breast cancer. Despite the positive results that have led to the approval of immunotherapy in both early- and advanced-stage triple-negative breast cancer, pivotal clinical trials cannot address the myriad questions arising in everyday clinical practice, often falling short in delivering all the information that clinicians require. In this manuscript, we aim to address some of these practical questions, with the purpose of providing clinicians with a guide for optimizing the use of immune checkpoint inhibitors in the management of breast cancer patients and identifying opportunities for future research to clarify unresolved questions.
View Article and Find Full Text PDFWe explored the dysregulation of G-protein-coupled receptor (GPCR) ligand systems in cancer transcriptomics datasets to uncover new therapeutics opportunities in oncology. We derived an interaction network of receptors with ligands and their biosynthetic enzymes. Multiple GPCRs are differentially regulated together with their upstream partners across cancer subtypes and are associated to specific transcriptional programs and to patient survival patterns.
View Article and Find Full Text PDFBackground: Nausea and vomiting are common side effects of Trastuzumab Deruxtecan (T-DXd), but guidelines for optimal management were not initially available. This retrospective single-center study aimed at evaluating the efficacy of two antiemetic regimens in patients receiving T-DXd.
Methods: Data from metastatic breast cancer patients receiving T-DXd were collected.