"Living Well with Chronic Pain": Integrative Pain Management via Shared Medical Appointments.

Objective: To evaluate the effectiveness of a multidisciplinary, nonpharmacological, integrative approach that uses shared medical appointments to improve health-related quality of life and reduce opioid medication use in patients with chronic pain.

Design: This is a retrospective, pre-post review of "Living Well with Chronic Pain" shared medical appointments (August 2016 through May 2018).

Setting: The appointments included eight 3-hour-long visits held once per week at an outpatient wellness facility.

Predictors for electronic survey completion in healthcare research.

Few studies have examined patients' preferences for and predictors of completing health surveys by paper versus Internet. The purpose of this study was to examine if participants of registry research preferred to complete health surveys by the Internet or paper, and if demographics and previous computer experiences were associated with health survey completion method preference. Using a descriptive design and convenience sample, participants of colorectal surgery registries completed an 18-item survey about Internet use and personal characteristics.

An experimental methodology for measuring volume changes in proton transfer reactions in aqueous solutions.

A fast perturbation in proton concentration can be induced in aqueous solution using a pulsed ultraviolet laser and suitable photolabile compounds which, upon photoexcitation, irreversibly release protons. The volume change and the rate constant for the reaction of the photodetached protons with proton-accepting groups in solution can be monitored using time resolved photoacoustics. A typical proton concentration jump of 1 microM can be obtained with a 200-microJ laser pulse at 308 nm.

Kinetics of histidine deligation from the heme in GuHCl-unfolded Fe(III) cytochrome C studied by a laser-induced pH-jump technique.

We have developed an instrumental setup that uses transient absorption to monitor protein folding/unfolding processes following a laser-induced, ultrafast release of protons from o-nitrobenzaldehyde. The resulting increase in [H(+)], which can be more than 100 microM, is complete within a few nanoseconds. The increase in [H(+)] lowers the pH of the solution from neutrality to approximately 4 at the highest laser pulse energy used.