Publications by authors named "L Letourneau"
Heart failure is a clinical syndrome that has become a leading public health problem worldwide. Globally, nearly 64 million individuals are currently affected by heart failure, causing considerable medical, financial, and social challenges. One therapeutic option for patients with advanced heart failure is mechanical circulatory support (MCS) which is widely used for short-term or long-term management.
View Article and Find Full Text PDFObjectives: Delays in treatment time intervals have been associated with overall survival in oral cavity squamous cell carcinoma (OCSCC). The aim of this study was to identify bottlenecks leading to prolonged treatment intervals.
Material And Methods: A retrospective analysis was conducted using a cohort of OCSCC patients who underwent surgery and adjuvant radiation therapy.
Article Synopsis
- A study investigated the role of tumor genomics in predicting recurrence risk for patients with localized clear-cell renal cell carcinoma (ccRCC) after surgery, using a large cohort of 943 cases.
- Researchers analyzed the mutation status of 12 genes, particularly focusing on von-Hippel Lindau (VHL) mutations, finding distinct groups with different disease-free survival rates.
- The results suggest that genomic profiling can help tailor adjuvant treatment decisions, with patients having only a VHL mutation possibly needing less aggressive therapy compared to those with additional mutations.
Rural states and communities continue to face significant challenges as they work to address the ongoing opioid epidemic and to implement specific strategies for prevention and treatment of opioid use disorder (OUD) and other substance use disorders (SUDs). While a growing number of innovative strategies have been identified that can offer promise for rural communities, state and clinical leaders from rural communities will need to identify evidence-based approaches that can work best in their communities, and ways to tailor options to meet their unique needs. This article identifies a set of five considerations for rural states and communities as they continue their work to identify solutions to this deadly epidemic.
View Article and Find Full Text PDFBackground: Rupture of spinal aneurysms is a rare cause of subarachnoid hemorrhage. These aneurysms are often associated with a variety of vascular malformations that increase blood flow in the spinal circulation or with disorders that compromise the vessel wall. However, spinal aneurysms may be isolated, not associated with any known predisposing condition.
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