Switching from onabotulinum toxin A to abobotulinum toxin A for treating detrusor overactivity in spinal cord injured patient, does it really work?

Aim: To assess the efficacy of switching to Abobotulinumtoxin A (ATA) intradetrusor injections (IDI) after failure of Onabotulinumtoxin A (OTA) IDI for the treatment of neurogenic detrusor overactivity in patients with spinal cord injury (SCI).

Materials And Methods: A single-centre retrospective chart review study. All SCI patients who started OTA IDI after 2011 and had an ATA IDI switch were included.

[External sphincterotomy in neurological patients with detrusor sphincter dyssynergia: Short and mid-term results].

Background: To evaluate in the short and mid-term the success of external sphincterotomy (ES) in neurological patients with detrusor sphincter dyssynergia (DSD).

Methods: Retrospective, monocentric study, conducted in 51 patients who had a first ES between January 2003 and June 2018, with at least two years of follow-up. The success of ES was defined by maintenance of reflex voiding mode at the end of follow-up.

[Is hemodilution sufficient to avoid homologous blood transfusion in reduction mammaplasties?].

The unpredictability of blood loss during reductive mammoplasties induced the authors to use a blood-sparing technique so as to avoid homologous transfusions. Intentional isovolaemic haemodilution (IIH) was performed in 38 patients. Clinical and biological criteria were used for analyzing the results.

[Responsibility of psychotropic drugs in road accidents].

Serum concentrations of psychotropic drugs were measured in 363 drivers injured in road accidents and admitted to the emergency department of Angers regional university hospital. The figures obtained were correlated to the presumed responsibility of each driver in the accident. Benzodiazepines and phenobarbitone were found in the serum of 39 drivers, and responsibility was significantly increased in this group.