Publications by authors named "L Leon"
What are parents' preferences for Human Papillomavirus vaccination promotion messages and communication? Application of a discrete choice experiment to a French Caribbean setting.
BMC Public Health
January 2025
Introduction: Human Papillomavirus (HPV) vaccine uptake in the French Caribbean has remained below 25% since introduction in 2007, which is well behind national and international targets. Using a discrete choice experiment (DCE), we explored parental preferences around HPV vaccination and optimized communication content in a sample of parents of middle-school pupils in Guadeloupe.
Methods: We conducted a cross-sectional survey in public and private middle age schools in Guadeloupe in June 2023 using an online questionnaire.
Article Synopsis
- BFL1, an antiapoptotic protein from the BCL2 family, is linked to hematological cancers but hasn't been extensively researched.
- Two articles present the development of selective BFL1 inhibitors, starting from hit identification using a covalent fragment library and leading to optimized compounds.
- One compound not only induced cell death in specific cancer cell lines but also stabilized the BFL1 protein, significantly increasing its half-life to 10.8 hours while activating cellular apoptosis markers.
MicroRNAs (miRNAs) can act as biomarkers and descriptors of the association between infections and other diseases, such as hepatitis and COVID-19. This study aims to investigate the role of miRNA serum expression according to laboratory data concerning hepatitis and COVID-19. Seventy individuals recruited in Southern and Southeastern Brazil donated serum samples and were divided into four groups: (i) 20 negative subjects, (ii) 20 presenting hepatitis, (iii) 19 with COVID-19 and (iv) 11 with hepatitis and COVID-19.
View Article and Find Full Text PDFArticle Synopsis
- A new collection of articles is launched that focuses on the intersection of coacervation and systems chemistry.
- The Guest Editors emphasize the significance of blending these two fields of research.
- They also point out the current challenges researchers face in this combined area of study.
Article Synopsis
- Current strategies to control Verticillium wilt of olive (VWO) are limited, highlighting the need for new approaches in olive crossbreeding programs.
- This study analyzed the basal metabolome of 43 olive cultivars with different resistance levels, using a cutting-edge UHPLC-ESI-TimsTOF MS/MS platform to identify over 70 metabolites across olive organs (roots, stems, and leaves).
- Significant differences in the metabolome were found between resistant and susceptible cultivars, with stem tissue showing the most potential for distinguishing between them, identified by key markers related to VWO susceptibility.