Publications by authors named "L Lecca"

Unlabelled: Welding fumes are a main source of occupational exposure to particulate matter (PM), besides gases and ultraviolet radiations, that involves millions of operators worldwide and is related to several health effects, including lung cancer. Our study aims to evaluate the exposure to fine and ultrafine airborne particulate in welding operators working in a steel making factory.In October 2019, air monitoring was performed for four days in five different welding scenarios and in the external area of a steelmaking factory to assess the exposure to airborne particles, ultrafine (UFP) particulate and inhalable fraction, during welding activities.

View Article and Find Full Text PDF

Objective: We adapted a mobile TB screening unit to create an integrated screening program for noncommunicable diseases and TB, using community health worker (CHW) navigators to support linkage to care. We piloted the model in underserved communities of Lima, Peru, evaluating its feasibility, acceptability, and ability to continue supporting TB case detection.

Design: The program provided screening for TB, hypertension, diabetes, and depression and was rebranded to avoid TB-associated stigma.

View Article and Find Full Text PDF

Background: Multidrug-resistant tuberculosis (MDR/RR-TB) is a major global health challenge, disproportionately affecting low- and lower-middle-income countries (LLMICs). The World Health Organization (WHO) generates guidance to address the problem. Here, we explore the extent to which guidance and related knowledge are generated by experts living in the most-affected countries and consider the results in the context of the movement to decolonize global health.

View Article and Find Full Text PDF

Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.

View Article and Find Full Text PDF
Article Synopsis
  • Approximately 40% of global tuberculosis cases go undiagnosed, with lower lung field TB (LLF TB) frequently misidentified as other lung issues, causing treatment delays.
  • An observational study in Lima, Peru, found that among 1316 pulmonary TB patients, 6% had LLF TB, which tended to be smear-negative, indicating a less typical presentation of the disease.
  • LLF TB patients showed less improvement in their respiratory health after 2 months of treatment, yet they had better final treatment outcomes compared to those with non-LLF TB, highlighting the need for optimized care for this specific group.
View Article and Find Full Text PDF