Publications by authors named "L Leanza"
Cycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem and explore the fundamental and functional properties of CPP rotaxanes and catenanes, researchers have resorted to unusual non-covalent and even to labor-intensive covalent template approaches. Herein, we report a ring-in-ring non-covalent template strategy that makes use of the surprisingly strong non-covalent inclusion of crown ethers into suitably sized CPPs.
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- Multilayer vesicles, or nano onions, can be formed through the self-assembly of amphiphilic gold(pyrazolate) complexes in water, showcasing a new approach distinct from typical organic amphiphiles.
- Characterization techniques like electron microscopy and dynamic light scattering confirmed the unique structures, highlighting that the presence of Au(I) is crucial compared to similar silver and copper complexes.
- Molecular dynamics simulations helped explain how these nano onions form through interactions between stacked complexes, providing a deeper understanding of their assembly in solution.
Selective metabolic regulations by p53 mutant variants in pancreatic cancer.
J Exp Clin Cancer Res
November 2024
Background: Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. However, the clinical significance of p53 GOF mutations, as well as the selectivity of individual variants, remains controversial and unclear.
View Article and Find Full Text PDFKv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear.
View Article and Find Full Text PDFObjectives: Neural stem/progenitor cells derived from olfactory neuroepithelium (hereafter olfactory neural stem/progenitor cells, ONSPCs) are emerging as a potential tool in the exploration of psychiatric disorders. The present study intended to assess whether ONSPCs could help discern individuals with schizophrenia (SZ) from non-schizophrenic (NS) subjects by exploring specific cellular and molecular features.
Methods: ONSPCs were collected from 19 in-patients diagnosed with SZ and 31 NS individuals and propagated in basal medium.