Publications by authors named "L Lazo"
Zika virus (ZIKV) infection remains a global public health problem. After the "Public Health Emergencies of International Concern" declared in February 2016, the incidence of new infections by this pathogen has been decreasing in many areas. However, there is still a likely risk that ZIKV will spread to more countries.
View Article and Find Full Text PDFArticle Synopsis
- Despite the development of COVID-19 vaccines, there are concerns regarding their safety and effectiveness, particularly in inducing mucosal immunity.
- The study investigates a new vaccine component by combining the nucleocapsid (N) protein from the Delta variant with a synthetic adjuvant, ODN-39M, and tests its effects in Balb/C mice.
- Results show that intranasal administration of this combination generates a strong immune response, producing IgA in the lungs and neutralizing antibodies, making it a promising candidate for a more effective intranasal vaccine against various Sarbecoviruses.
Zika virus infection continues to be a global concern for human health due to the high-risk association of the disease with neurological disorders and microcephaly in newborn. Nowadays, no vaccine or specific antiviral treatment is available, and the development of safe and effective vaccines is yet a challenge. In this study, we obtained a novel subunit vaccine that combines two regions of zika genome, domain III of the envelope and the capsid, in a chimeric protein in E.
View Article and Find Full Text PDFSince the beginning of the COVID-19 pandemic, the development of effective vaccines against this pathogen has been a priority for the scientific community. Several strategies have been developed including vaccines based on recombinant viral protein fragments. The receptor-binding domain (RBD) in the S1 subunit of S protein has been considered one of the main targets of neutralizing antibodies.
View Article and Find Full Text PDFConcordance Between Clinical and Laboratory Diagnosis of Abnormal Vaginal Discharge in Chilean Women.
Rev Bras Ginecol Obstet
August 2021
Objective: To determine the concordance between the clinical diagnosis of women with abnormal vaginal discharge (AVD) and laboratory results using molecular detection and observation of the vaginal microbiota.
Methods: Cross-sectional study conducted in 2018 in Temuco, Chile. A total of 25 midwives from 12 health centers participated.