EpiSegMix: a flexible distribution hidden Markov model with duration modeling for chromatin state discovery.

Motivation: Automated chromatin segmentation based on ChIP-seq (chromatin immunoprecipitation followed by sequencing) data reveals insights into the epigenetic regulation of chromatin accessibility. Existing segmentation methods are constrained by simplifying modeling assumptions, which may have a negative impact on the segmentation quality.

Results: We introduce EpiSegMix, a novel segmentation method based on a hidden Markov model with flexible read count distribution types and state duration modeling, allowing for a more flexible modeling of both histone signals and segment lengths.

A Trans∗ Zapping of Psychoanalysis.

In France, transsexualism was introduced in psychoanalysis through the mediation of medicine. The statements of psychoanalysts on transgender people are considered as offensive by the people concerned. Since the 1970s, trans∗ people have refused to be objectified as "clinical cases" and have decided to "zap" psychoanalysis, the vehicle for a violent, discriminatory rhetoric redolent of psychiatry.

Transport of Flexible, Oil-Soluble Diblock and BAB Triblock Copolymers to Oil/Water Interfaces.

The connection between block copolymer architecture and adsorption at fluid/fluid interfaces is poorly understood. We characterize the interfacial properties of a well-defined series of polyethylene oxide/polydimethyl siloxane (PDMS) diblock and BAB triblock copolymers at the dodecane/water interface. They are oil-soluble and quite flexible because of their hydrophobic PDMS block.

The Therapist's Transition.

Eager to distance himself from the clinical mistreatment and theoretical arrogance shown toward a gender-variant population, a self-identified cis-gendered male clinician-researcher narrates his experiences, difficulties, and doubts from a psychoanalytic standpoint in his interactions with a transgender adult in an institutional setting. He thus addresses from a pluralistic perspective the intrapsychic concerns and sociocultural norms that contribute to the patient's suffering, as well as the therapist's own vulnerability and countertransference challenges in this situation. By reflecting on the very traps that he fell into when writing a previous version of this article, the author proposes a focused narrative, co-signed by his supervisor, to provide the reader with a cautionary tale of how easily a clinician's efforts to understand may devolve into objectifications embedded in the history of analytic thinking.

Autoimmune Progesterone Dermatitis Mistaken for Stevens-Johnson Syndrome.

Background: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.

Case: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome.