Publications by authors named "L Lasagni"
Article Synopsis
- * In a study of pediatric and adult patients, a significant portion showed IgG antibodies localizing to kidney proteins, but the presence of these antibodies varied, indicating potential involvement of other proteins.
- * Patients with anti-slit antibodies were more likely to develop nephrotic syndrome and showed a higher response rate to second-line immunosuppressants, while those without these antibodies had a greater risk of kidney failure.
Kidney regeneration is hindered by the limited pool of intrinsic reparative cells. Advanced therapies targeting renal regeneration have the potential to alleviate the clinical and financial burdens associated with kidney disease. Delivery systems for cells, extracellular vesicles, or growth factors aimed at enhancing regeneration can benefit from vehicles enabling targeted delivery and controlled release.
View Article and Find Full Text PDFArticle Synopsis
- - Chronic kidney disease affects about 10% of people globally and can lead to serious health issues; understanding its genetic factors is crucial, especially in younger patients.
- - Researchers can isolate renal progenitors from urine to create disease models, which aid in diagnosing genetic kidney diseases and testing new treatments.
- - Urine-derived renal progenitors are a noninvasive and efficient way to enhance diagnosis and treatment options, contributing to more personalized healthcare approaches.
The association between MPO-ANCA-associated vasculitis (AAV) and interstitial lung disease (ILD) has been well established. Pulmonary fibrosis may coexist with, follow, or even precede the diagnosis of AAV, and its presence adversely affects the prognosis. The optimal approach to investigating ANCA in patients with ILD remains a subject of ongoing debate.
View Article and Find Full Text PDFBackground: The glomerulus is a highly complex system, composed of different interdependent cell types that are subjected to various mechanical stimuli. These stimuli regulate multiple cellular functions, and changes in these functions may contribute to tissue damage and disease progression. To date, our understanding of the mechanobiology of glomerular cells is limited, with most research focused on the adaptive response of podocytes.
View Article and Find Full Text PDF