Publications by authors named "L Lasagna"
Article Synopsis
- Recent research highlights the glymphatic system's role in neurodegeneration, leading to the development of a new analysis method called DTI-ALPS for assessing brain health.
- This study conducts a Bayesian meta-analysis on 12 Parkinson's and 11 Alzheimer's studies to evaluate the reliability of DTI-ALPS across different research, aiming to differentiate between these disorders.
- Findings indicate that DTI-ALPS consistently reflects the glymphatic system's health in both diseases and could serve as a valuable tool in diagnosing and understanding neurodegenerative conditions.
Background: Studies show that abnormalities in non-coding genes can contribute to carcinogenesis; microRNA levels may modulate cancer growth and metastatic diffusion.
Method: MicroRNA libraries were built and sequenced from two osteosarcoma cell lines (MG-63 and 143B), which differ in proliferation and transmigration. By cloning and transfection, miR-93, expressed in both cell lines, was then investigated for its involvement in osteosarcoma progression.
The T lymphocyte-mediated immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy is unknown. The aim of this study was to investigate the immune response in the parietal pleura of tuberculous pleurisy compared with nonspecific pleuritis. We have measured the numbers of inflammatory cells particularly T-cell subsets (Th1/Th2/Th17/Treg cells) in biopsies of parietal pleura obtained from 14 subjects with proven tuberculous pleurisy compared with a control group of 12 subjects with nonspecific pleuritis.
View Article and Find Full Text PDFThe placebo effect has been the subject of much controversy. For a scientific investigation of placebo effects to advance it is important to establish whether a placebo response in any particular illness is reliable - i.e.
View Article and Find Full Text PDFLittle is known about placebo effects with scientific precision. Poor methodology has confounded our understanding of the magnitude and even the existence of the placebo effect. Investigating placebo effects presents special research challenges including: the design of appropriate controls for studying placebo effects including separating such effects from natural history and regression to the mean, the need for large sample sizes to capture expected small effects, and the need to understand such potential effects from a patient's perspective.
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