Publications by authors named "L Langer"
Article Synopsis
- - The study focuses on the relationship between mRNA translation and decay in human cells, specifically highlighting the role of the cytoplasmic exosome in degrading mRNA linked to ribosomes during quality control.
- - Researchers identified that HBS1L3 (SKI7) facilitates a direct physical coupling between EXO10 and the ribosome-bound SKI238 complex, enabling efficient mRNA handover for degradation.
- - They discovered that the decay process involves a supercomplex formed by the exosome and ribosome, allowing mRNA to be efficiently threaded from the ribosome through the helicase to the exoribonuclease, effectively coordinating the decay mechanism.
Objective: To describe and compare adverse event (AE) incidence, type, severity, and preventability in the Canadian inpatient rehabilitation setting.
Design: In this retrospective case series, AEs were identified through chart reviews from two Canadian academic tertiary post-acute care hospitals. AEs were characterized through descriptive statistics and compared using the Mantel-Haenszel and Fisher's exact tests.
Purpose: To describe the therapy approaches and clinical outcomes of an integrated care model for patients with functional movement disorder (FMD).
Materials And Methods: A retrospective chart review was conducted for all treated individuals with a primary diagnosis of FMD between January 2020 and July 2022. Patients received time-limited integrated therapy ( = 21) (i.
Nonsense-mediated mRNA decay (NMD) is a conserved co-translational mRNA surveillance and turnover pathway across eukaryotes. NMD has a central role in degrading defective mRNAs and also regulates the stability of a significant portion of the transcriptome. The pathway is organized around UPF1, an RNA helicase that can interact with several NMD-specific factors.
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- Acid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disease in Germany with various clinical forms, necessitating more data on survival and health outcomes in affected patients.
- A retrospective study analyzed medical records of 33 patients diagnosed with ASMD type B or A/B between 1990 and 2021, focusing on demographics, medical history, hospitalizations, and mortality rates.
- The study found a high mortality rate, especially in patients under 18, with median ages at diagnosis of 8 years for type B and 1 year for type A/B, revealing that liver and respiratory issues were the leading causes of death.