Publications by authors named "L Lange"
Recent advancements in Parkinson's disease (PD) drug development have been significantly driven by genetic research. Importantly, drugs supported by genetic evidence are more likely to be approved. While genome-wide association studies (GWAS) are a powerful tool to nominate genomic regions associated with certain traits or diseases, pinpointing the causal biologically relevant gene is often challenging.
View Article and Find Full Text PDFAims/hypothesis: This is the first study to examine the association between variants of the glucagon-like-peptide-1 receptor gene (GLP-1R) and metabolic characteristics among youth. We explored separate associations of three GLP-1R polymorphisms (rs10305420, rs6923761, and rs1042044) with BMI trajectories and markers of glucose-insulin homeostasis.
Methods: Mixed models examined associations between GLP-1R polymorphisms and trajectories of BMI.
The pulp of açaí palm fruits ( Mart.) is a valuable export commodity in Brazil. Its production generates 1.
View Article and Find Full Text PDFArticle Synopsis
- Frontal alpha asymmetry was thought to indicate levels of approach motivation, but recent studies found little connection between it and personality traits.
- A study using data from the CoScience project (n=740) measured frontal asymmetry during different tasks to see if it varied based on approach motivation.
- The results showed that frontal asymmetry wasn't significantly influenced by the tasks and did not correlate with self-reported personality traits, undermining its validity as a marker for approach motivation.
Article Synopsis
- The release of Genome Aggregation Database (gnomAD) v4 significantly increases sample size, impacting the interpretation of genetic variants, particularly in dystonia.
- A comparison of variants linked to common forms of isolated dystonia showed that most (77.7%) remained absent in the new version; however, some well-known pathogenic variants were newly recorded in v4.
- Despite finding more dystonia-related alleles in gnomAD v4, the authors stress that the presence of these variants in population data doesn't automatically mean they aren't pathogenic.