Publications by authors named "L Landraud"

We report 72 metagenome-assembled genomes (MAGs) of recovered from the vaginal microbiomes of pregnant women. The MAGs have an estimated median genome size of 5.1 Mb (IQR 4.

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Article Synopsis
  • The study investigates the impact of vaginal microbiota (VM) on asymptomatic bacteriuria (ASB) in 1,553 pregnant women, highlighting the dominance of E. coli as a common cause of bacteriuria and newborn infections.
  • Results indicate that a healthy VM, usually rich in Lactobacillus species, is disturbed during bacteriuria, leading to an increase in harmful gut-associated bacteria, particularly E. coli.
  • Molecular analysis of E. coli genomes reveals the presence of extraintestinal pathogenic strains, suggesting that reduced Lactobacillus abundance may enable opportunistic pathogens to thrive, thereby compromising women's health during pregnancy.
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It has been shown that an evolutionary tradeoff between vertical (host growth rate) and horizontal (plasmid conjugation) transmissions contributes to global plasmid fitness. As conjugative IncC plasmids are important for the spread of multidrug resistance (MDR), in a broad range of bacterial hosts, we investigated vertical and horizontal transmissions of two multidrug-resistant IncC plasmids according to their backbones and MDR-region rearrangements, upon plasmid entry into a new host. We observed plasmid genome deletions after conjugation in three diverse natural clinical strains, varying from null to high number depending on the plasmid, all occurring in the MDR region.

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Toxoplasmosis is a ubiquitous parasitic infection caused by Toxoplasma gondii (Tg). In immunocompetent people, the infection may be asymptomatic with the induction of an immune response that may prevent reinfection or transmission to the fetus in immune pregnant woman. In immunocompromised persons or seronegative pregnant woman with a primary infection during pregnancy, the infection may result in the loss of life, sight, cognition, and motor function in the immune-compromised person or immunologically immature fetus.

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Multiresistance plasmids belonging to the IncI incompatibility group have become one of the most pervasive plasmid types in extended-spectrum beta-lactamase-producing of animal origin. The extent of the burden imposed on the bacterial cell by these plasmids seems to modulate the emergence of "epidemic" plasmids. However, data in the natural environment of the strains are scarce.

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