Publications by authors named "L Lalli"
Article Synopsis
- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Article Synopsis
- - The study analyzed how anthracycline-based neoadjuvant chemotherapy (NAC) affects immune cells' spatial distribution in high-risk soft tissue sarcomas (STS) and how this relates to patient outcomes.
- - Researchers examined various tumor areas for specific immune cells using advanced pathology techniques and created a sarcoma immune index (SIS) to predict disease-free and overall survival rates.
- - Findings revealed that certain immune cell types, particularly PD-1+ and CD20+ B-cells, correlated with prognosis differently based on their locations within the tumor, highlighting NAC's role in altering tumor immune characteristics.
Molecular diagnostics involving nucleic acids (DNA and RNA) are regarded as extremely functional tools. During the 2020 global health crisis, efforts intensified to optimize the production and delivery of molecular diagnostic kits for detecting SARS-CoV-2. During this period, RT-LAMP emerged as a significant focus.
View Article and Find Full Text PDFObjective: To assess the role of histopathological and molecular features in predicting the risk of nodal metastases in apparent early-stage endometrial cancer patients undergoing sentinel node mapping.
Methods: This is a prospective trial. Consecutive patients with apparent early-stage endometrial cancer, undergoing laparoscopic hysterectomy, bilateral salpingo-oophorectomy, and sentinel node mapping, were enrolled.