Publications by authors named "L Lagneaux"
Extracellular vesicles from chronic lymphocytic leukemia cells promote leukemia aggressiveness by inducing the differentiation of monocytes into nurse-like cells via an RNA-dependent mechanism.
Hemasphere
January 2025
Chronic lymphocytic leukemia (CLL) cells receive several stimuli from surrounding cells, such as B-cell receptor (BCR) stimulation, and can manipulate their microenvironment via extracellular vesicle (EV) release. Here, we investigated the small RNA content (microRNA and YRNA) of CLL-EVs from leukemic cells cultured with/without BCR stimulation. We highlight an increase of miR-155-5p, miR-146a-5p, and miR-132-3p in EVs and in cells after BCR stimulation ( < 0.
View Article and Find Full Text PDFMedication-related osteonecrosis of the jaw (MRONJ) poses a significant challenge considering the absence of a "gold standard" treatment. Cell-based therapy and tissue engineering offer promising therapeutic alternatives. This study aimed to harness the regenerative properties of adipose-tissue stromal vascular fraction (AT-SVF) and leukocyte-platelet-rich fibrin (L-PRF) for MRONJ treatment.
View Article and Find Full Text PDFArticle Synopsis
- Mesenchymal stromal cells (MSC) are important for tissue regeneration and immune regulation, but aging affects their function, leading to "inflammaging" and increased disease risk in the elderly, including cancer.
- The study aimed to analyze differences in morphology, gene expression, and function between MSC from young and old healthy donors by using various inflammatory markers and techniques.
- Results showed that aging MSC exhibited changes such as increased size and oxidative stress levels, impaired functionality, and altered gene expression, particularly in their ability to modulate immune responses.
Article Synopsis
- Extracellular vesicles (EVs), discovered in the late 20th century, play a crucial role in cancer development, particularly in blood-related cancers due to their ability to facilitate communication between cells.
- These vesicles include small EVs (exosomes) and large EVs (microparticles), which exchange proteins, DNA, and RNA, impacting tumor growth and the surrounding microenvironment.
- Current research is focused on their effects and potential treatments for hematological malignancies, with promising advances in understanding their role in disease detection and management.