Publications by authors named "L Labache"
Background: Exposure to major life stressors and aberrant functional connectivity have been linked to anxiety and depression, especially during adolescence. However, whether specific characteristics of life stressors and functional network connectivity act together to differentially predict anxiety and depression symptoms remains unclear.
Methods: We utilized baseline lifetime stressor exposure and resting-state functional magnetic resonance imaging data in a longitudinal sample of 107 adolescents enriched for anxiety and depressive disorders.
Article Synopsis
- - The study investigates how brain mechanisms related to cocaine use disorder involve both cortical and subcortical systems, emphasizing the importance of large-scale functional brain networks and the dopamine system.
- - Previous research predominantly focused on cortico-striatal circuits, but this study shifts attention to how functional connectivity patterns are associated with neurotransmitter receptor densities in cocaine users.
- - Findings reveal that specific patterns of connectivity in the brains of individuals with cocaine use disorder correspond with the spatial densities of dopamine D receptors, suggesting that these receptor distributions may influence brain connectivity associated with substance use.
The human brain experiences functional changes through childhood and adolescence, shifting from an organizational framework anchored within sensorimotor and visual regions into one that is balanced through interactions with later-maturing aspects of association cortex. Here, we link this profile of functional reorganization to the development of ventral attention network connectivity across independent datasets. We demonstrate that maturational changes in cortical organization link preferentially to within-network connectivity and heightened degree centrality in the ventral attention network, whereas connectivity within network-linked vertices predicts cognitive ability.
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- The study aims to connect brain functioning profiles with symptoms and behaviors in psychiatric patients by introducing a new dataset.
- This dataset includes brain imaging and behavioral data from 241 individuals, with a mix of 148 people diagnosed with psychiatric illnesses and a healthy group of 93.
- It provides a comprehensive resource including high-resolution scans, fMRI data, and over 50 psychological assessments to facilitate research in neuroscience.
Aging engenders neuroadaptations, generally reducing specificity and selectivity in functional brain responses. Our investigation delves into the functional specialization of brain hemispheres within language-related networks across adulthood. In a cohort of 728 healthy adults spanning ages 18 to 88, we modeled the trajectories of inter-hemispheric asymmetry concerning the principal functional gradient across 37 homotopic regions of interest (hROIs) of an extensive language network, known as the Language-and-Memory Network.
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