METTL4 and METTL5 as biomarkers for recurrence-free survival in hepatocellular carcinoma patients.

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with high rates of postoperative recurrence. Identifying reliable biomarkers for predicting recurrence is critical for improving patient outcomes. This study investigates the predictive value of m6A methylation-related genes, METTL4 and METTL5, on HCC recurrence after surgery.

Polystyrene nanoplastics sequester the toxicity mitigating potential of probiotics by altering gut microbiota in grass carp (Ctenopharyngodon idella).

This study evaluated the role of probiotics in enhancing intestinal immunity and mitigating polystyrene nanoplastics (PS-NPs)-induced toxicity in grass carp (Ctenopharyngodon idella). Grass carp were fed probiotics (Bacillus subtilis, Bacillus velezensis, Lactobacillus reuteri, and Lactococcus lactis) for two weeks before being exposed to PS-NPs for five days. Probiotic pretreatment alleviated PS-NPs-induced intestinal damage, with Bacillus velezensis and Lactococcus lactis groups showing milder vacuolation and villus breakage than other groups.

Degradation of 1,2,3-trichloropropane by ferrate(VI) oxidant: Mechanisms, influencing factors and oxidative iron species.

The ferrate(VI) ion is a green, versatile oxidant employed eliminate organic contaminants. Research on the degradation of saturated chlorinated hydrocarbons such as 1,2,3-trichloropropane (1,2,3-TCP), by Fe(VI) is limited. In this study, we investigated the degradation of 1,2,3-TCP by Fe(VI).

Longitudinal changes in plasma Cystatin C and all-cause mortality risk among the middle-aged and elderly Chinese population.

Objective: Elevated plasma Cystatin C levels are associated with an increased mortality risk among middle-aged and elderly Chinese individuals. This study explores whether tracking the longitudinal changes in Cystatin C can improve the prediction of mortality risk and allow better risk stratification, jointly with baseline measurements.

Design & Methods: This analysis includes 3,195 participants from the China Health and Retirement Longitudinal Study who completed plasma Cystatin C measurements in two waves (2011 and 2015) and were followed through 2020.

Hydrogen Radical Enabling Industrial-Level Oxygen Electroreduction to Hydrogen Peroxide.

The electrochemical synthesis of hydrogen peroxide from oxygen and water, powered by renewable electricity, provides a highly attractive alternative to the energy-intensive autoxidation process presently used in industry, but much remains unknown about this two-electron oxygen reduction reaction (2e-ORR), especially the local proton effect. Here, we have investigated the function of hydrogen-associated intermediates in the 2e-ORR using a rationally designed cooperative electrode material with cobalt (II) clusters embedded onto the oxidized carbon nanotube composites (Co-OCNT). We found that the local proton availability can determine both the reaction kinetics and selectivity.