[The structural status of red blood cell membranes in children with insulin-dependent diabetes mellitus. Examination by spin probe].

Using spin probes-stearic acid analogues, the authors investigated the microviscosity and the a/b parameter of red blood cell membranes in children with diabetes mellitus. The structural changes were correlated with altered metabolic measurements. The change in the pathway of insulin in diabetes mellitus led to the structural state of red blood cell membranes.

[Hormonal-metabolic disorders in children with diabetes mellitus in the preclinical stage of diabetic retinopathy].

A relationship was established between alterations in vessels of the fundus of the eye and diabetes mellitus standing, the character of metabolic disorders, hereditary load with regard to cardiovascular diseases. The risk factors of the development of the preclinical stage of diabetic retinopathy are as follows: hereditary load with regard to cardiovascular diseases, parship, an increase of the content of lactate, a reduction of the content of 2,3-diphosphoglycerophosphate, a rise of the content of glycosylated hemoglobin, high content of cholesterol esters in red blood cell membranes, of free cholesterol and malonic dialdehyde in blood serum, a decline of the level of phospholipids and a rise of cardiolipin content in red blood cell membranes, and increase of blood serum cortisol.

[The role of thromboxane A2 and prostacyclin in the pathogenesis of diabetes mellitus in children and adolescents].

The follow-up of children and adolescents (n-41) suffering from insulin-dependent diabetes mellitus has demonstrated that the increase of the thromboxane/prostacyclin ratio pointing to the derangement of microcirculatory regulation occurs during the decompensation phase of the disease and is a risk factor of the development of diabetic complications. The revealed disorders of arachidonic acid metabolism may be one of the causes of the tendency towards decrease of pulse arterial pressure in grave diabetes mellitus.