Publications by authors named "L L Stempora"
Article Synopsis
- Natural killer (NK) cells play a crucial role in managing both viral infections and immune responses during kidney transplants in children, as shown in a study using data from the CTOTC project.
- The study analyzed NK cell phenotypes in 98 pediatric kidney transplant patients and found specific NK cell traits linked to either viral infections or alloimmune events, such as acute rejection.
- These findings suggest that understanding NK cell profiles could help distinguish between risk factors for infections versus those for immune responses after transplantation.
Objectives: To characterize and quantify accumulating immunologic alterations, pre and postoperatively in patients undergoing elective surgical procedures.
Background: Elective surgery is an anticipatable, controlled human injury. Although the human response to injury is generally stereotyped, individual variability exists.
Background: Thoracic injury can cause impairment of lung function leading to respiratory complications such as pneumonia (PNA). There is increasing evidence that central memory T cells of the adaptive immune system play a key role in pulmonary immunity. We sought to explore whether assessment of cell phenotypes using flow cytometry (FCM) could be used to identify pulmonary infection after thoracic trauma.
View Article and Find Full Text PDFBackground: An emerging body of literature supports the role of individualized prognostic tools to guide the management of patients after trauma. The aim of this study was to develop advanced modeling tools from multidimensional data sources, including immunological analytes and clinical and administrative data, to predict outcomes in trauma patients.
Methods: This was a prospective study of trauma patients at Level 1 centers from 2015 to 2019.
Background: Malnutrition, including obesity and undernutrition, among children is increasing in prevalence and is common among children on renal replacement therapy. The effect of malnutrition on the pre-transplant immune system and how the pediatric immune system responds to the insult of both immunosuppression and allotransplantation is unknown. We examined the relationship of nutritional status with post-transplant outcomes and characterized the peripheral immune cell phenotypes of children from the Immune Development of Pediatric Transplant (IMPACT) study.
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