Publications by authors named "L L Souza"
Background: Language impairment manifestations in patients with the semantic variant of primary progressive aphasia (S-PPA) include surface dysgraphia. Word and pseudoword dictation helps characterize errors in these patients' writing to better conduct their therapeutic strategies. Few studies have addressed written language in patients with dementia, and even fewer have done so in PPA.
View Article and Find Full Text PDFBackground: Language is frequently affected in patients with sporadic amyotrophic lateral sclerosis (sALS), with reduced performance in naming, syntactic comprehension, grammatical expression, and orthographic processing. In a previous study, we demonstrated that the language profile of patients with familial type 8 ALS (ALS8), linked to p.P56S VAPB mutation, is similar to sALS.
View Article and Find Full Text PDFBackground: Chalcones have been described in the literature as promising antineoplastic compounds.
Objectives: Therefore, the objective of this study was to analyze the cytotoxic effect of 23 synthetic chalcones on human acute leukemia (AL) cell lines (Jurkat and K562).
Methods: Cytotoxicity assessment was performed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.
The gain-of-function variant in the NLRP3 gene predicts the effectiveness of brief psychotherapy but not the risk of major depression.
Behav Brain Res
December 2024
Article Synopsis
- Major depressive disorder (MDD) is linked to neuroinflammatory processes involving the NLRP3 inflammasome, and a study examined the impact of the NLRP3 rs10754558 polymorphism on MDD diagnoses among young adults.
- A population-based study with 1,100 participants found no significant association between the NLRP3 genotype and MDD diagnosis, but a clinical trial showed that individuals with the GG genotype had poorer treatment outcomes compared to those with GC/CC genotypes.
- Longitudinal analyses indicated that GG individuals experienced less improvement in depressive and anxiety symptoms over time, suggesting that this genotype may affect the effectiveness of psychotherapy for MDD.
Although system justification-believing that the societal status quo is legitimate and desirable-is positively associated with subjective well-being and mental health outcomes for members of advantaged groups, the picture is more complicated for members of disadvantaged minority groups. According to system justification theory, believing that the social system is legitimate and desirable is a way of coping with one's own and fellow in-group members' state of disadvantage. At the same time, it is also a potential stressor, insofar as it implies that there are deficiencies of the individuals and groups who "fail" to succeed in a fair system.
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