Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.

Background: Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.

Methods: Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets.

Risk Factors for Diagnostic Change from Glaucoma Suspect to Primary Open-Angle Glaucoma and Vice Versa over Two Years.

Objective: This study investigates the incidence and causes of diagnostic changes from primary open angle glaucoma suspect (POAGS) to primary open angle glaucoma (POAG), and vice versa, in clinical practice.

Design: This is a retrospective, single site, case-control study.

Participants: It includes patients over age 40 diagnosed with either POAG or POAGS between 2013-2020.

Association of chronic exercise with markers of cardiometabolic health: a systematic review and meta-analysis.

Background: The impact of chronic exercise on cardiometabolic risk is a crucial aspect of public health. However, limited knowledge exists regarding differences in cardiometabolic parameters between older athletes, older controls, and sedentary or active young controls.

Methods: A comprehensive search in major databases until October 2024 was conducted for studies comparing older athletes with older controls or with both sedentary and active younger adults.

Clozapine rechallenge following myocarditis: a systematic review of rechallenge cases.

Introduction And Objectives: Clozapine is the antipsychotic medication with the greatest efficacy in treatment-resistant schizophrenia (TRS). Unfortunately, clozapine is ceased in approximately 0.2% to 8.

Integrating oral health into primary care: a proof-of-concept for dry mouth management in the Australian community pharmacy setting.

Background: Xerostomia (dry mouth) is a common yet severe problem, causing difficulty with eating, speaking, dental caries, and discomfort. Access issues to dental services, including cost and availability of dental practitioners, can delay timely diagnosis and management of dry mouth. Thus, there is a need for innovative approaches to manage xerostomia, involving non-dental primary care health practitioners.