Publications by authors named "L L Sim"
Given the complexities of continuous bioprocessing, it is critical to thoroughly investigate the process parameters unique to multi-column chromatography (MCC) and their potential impacts. However, existing studies have focused on either loading densities or residence time at steady states only, and their combined impact on critical quality attributes (CQAs) especially during transient phases were less known. In this study, we investigated the impact of critical process parameters during both steady-state and transient phases (start-up, close-down, and intermediate perturbation) through full factorial design.
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- The study investigates the effectiveness of the modified Hospital Frailty Risk Score (mHFRS) in identifying frail hospitalized older adults, comparing it with the original Hospital Frailty Risk Score (HFRS) and the Clinical Frailty Scale (CFS).
- A review of 3,042 patients over 65 years old was conducted, revealing that the CFS identified 46.3% as frail, with frail patients generally being older, more likely female, and having longer hospital stays and higher mortality rates.
- The mHFRS showed a significant correlation with both CFS and HFRS, proving to be effective in classifying patients, especially identifying non-frail individuals, and suggesting it as a
The coming decades will see a substantial increase in the population of older adults, accompanied by significant demographic and family structure changes worldwide. As a result, the empty nest period-the postparental phase in parents' lives when their children have left home and they are no longer engaged in childrearing-is becoming an increasingly common experience in Western and Asian cultures. The current theoretical review examines the psychological consequences of the empty nest period on loneliness and well-being across cultures, emphasizing the impact of cultural factors on these experiences.
View Article and Find Full Text PDFThe World Health Organization has designated Pseudomonas aeruginosa as a critical pathogen for the development of new antimicrobials. Bacterial viruses, or bacteriophages, have been used in various clinical settings, commonly called phage therapy, to address this growing public health crisis. Here, we describe a high-resolution structural atlas of a therapeutic, contractile-tailed Pseudomonas phage, Pa193.
View Article and Find Full Text PDFBackground: There is an increasing need to integrate Advance Care Planning (ACP) in nursing homes (NH) due to rapid aging and burden of multimorbidity. This study examines differences in the characteristics and outcomes of NH residents enrolled in a palliative care programme who have completed ACP and those who did not.
Method: We conducted a retrospective cohort analysis of 294 deceased residents enrolled into a palliative programme from 8 nursing homes in Singapore.