[Thrombocytic diseases in generalized myasthenia gravis and their correction by using plasmapheresis and administration of anti- immunoglobulin antisera].

Platelet adhesion and aggregation studies were performed in different test systems in 25 patients with plasmapheresis-treated myasthenia patients. In vivo studies with plasmapheresis and in vitro investigation with anti-immunoglobulin antisera revealed the normalization of the impaired platelet functions.

[Morphological changes in the internal organs in experimental staphylococcal sepsis].

In 200 albino rats pathomorphological changes of different organs were studied during experimental staphylococcal sepsis (from 3 to 45 days of the disease), caused by intramuscular injection of 0.15-0.20 ml suspension of microbes (10(15) per ml) in 10% CaCl2 solution.

[Inhibition of platelet aggregation by dinitrosyl iron complexes with low molecular weight ligands].

The dinitrosyl iron complexes (DNIC) with thiosulphate, cysteine or phosphate were shown to inhibit in vitro (in citrate plasma) the human platelet aggregation induced by ADP, collagen or adrenaline. This effect cannot be explained by the toxic action of DNIC on the platelet membrane, since DNIC-pretreated platelets are capable of aggregating under the action of 10(-8) M/ml of phorbol ester, which is known to cause direct activation of protein kinase C. The antiaggregatory activity of DNIC exceeds that of Na-nitroprusside and seems to be due to nitric oxide capable to activate guanylate cyclase of platelets.