Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites.

In current study, microstructural, mechanical and corrosion behaviour were investigated with incorporation of dual reinforced AZ91D surface composites. This research was carried out for enhancement of the bio-degradability in biological environment. The surface composites were successfully fabricated by friction stir processing method with a rotation speed of 800 rpm, travel speed of 80 mm/min and 2.

SLC13A2 promotes hepatocyte metabolic remodeling and liver regeneration by enhancing de novo cholesterol biosynthesis.

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain poorly defined. Here, we screened metabolic genes differentially regulated during liver regeneration, and report that SLC13A2, a transporter for TCA cycle intermediates, is decreased in rapid response to partial hepatectomy in mice and recovered along restoration of liver mass and function.

The impact of cortical and subcortical volumes on major depression risk: A genetic study.

Objective: This study aimed to explore the causal relationship between brain cortical and subcortical structures and major depressive disorder (MDD) using the Mendelian Randomization (MR) method.

Methods: Single nucleotide polymorphisms (SNPs) were used as instrumental variables to analyze subcortical brain volume, cortical thickness, and surface area as exposure factors, with MDD as the outcome. Multiple sensitivity analyses were conducted to validate the robustness of the results.

Design, synthesis, and antitumor evaluation of triazolopyridine derivatives as novel inhibitors for BRD4.

The bromodomain-containing protein 4 (BRD4) is an epigenetic regulatory 'reader' belonging to the bromodomain and extra-terminal domain (BET) family. Several studies have demonstrated that the high expression of BRD4 is closely related to the occurrence and development of various cancers, so BRD4 has become a promising target for cancer treatment. However, there are no drugs targeting BRD4 available on the market, the development of novel BRD4 inhibitors is of great significance.

DkGASA4 plays a role in the postharvest softening of persimmon fruit regulated by gibberellin.

Gibberellin (GA) is one of the crucial plant hormones involved in fruit ripening regulation. GASA genes, which respond to GA and encode cysteine-rich peptides, are prevalent in plants. While the GASA gene family has been identified in various plants, its role in persimmon fruit ripening remains unclear.