Laboratory readiness and genomic surveillance of Covid-19 in the capital of Brazil.

This study aims to analyze the diagnostic readiness to Covid-19 and the genomic surveillance of SARS-CoV-2 in Brasília, the capital of Brazil. This is a retrospective, cross-sectional study, with data from: cases/deaths-Ministry of Health; RT-PCR analyses Brasília Central Public Health Laboratory (LACEN); genomics-Global Initiative on Sharing All Influenza Data (GISAID). It was found that in March 2021, with the Gamma variant was predominant, RT-PCR diagnostic tests administered by LACEN reached their peak, followed by a reduction, possibly due to the start of vaccination.

Biomarkers.

Background: Glial fibrillary acidic protein (GFAP) is a putative blood biomarker for Alzheimer's disease (AD). Most studies measure plasma GFAP (pGFAP) utilizing the Single Molecule Array (Simoa) platform or other high-cost platforms. However, we aim to validate the value of GFAP as a blood biomarker for AD using chemiluminescent microparticle immunoassay (CMIA), an ubiquitous lower-cost platform.

Developing Topics.

Background: Dementia is a growing concern throughout the developing world and is severely underdiagnosed among the Brazilian population. Despite remarkable progress in the biomarker field in recent years, local testing and validation of plasma biomarkers of AD and dementia is still lacking in Brazil and Latin America.

Method: In this longitudinal cohort study of 145 participants, the diagnostic performance of plasma biomarkers was assessed based on clinical diagnosis and CSF biomarker positivity.

Association of systemic inflammation and long-term dysfunction in COVID-19 patients: A prospective cohort.

COVID-19 has significant long-term impacts, including a chronic syndrome known as long-COVID, characterized by persistent symptoms post-recovery. The inflammatory response during acute infection is hypothesized to influence long-term outcomes. This study aimed to identify inflammatory biomarkers predictive of functional outcomes one year after hospital discharge.

Listen, act and support: An investigation into individual and organisational incivility management in veterinary practice.

Background: This study investigates the impact of workplace and client incivility on veterinary staff wellbeing and job satisfaction, examining both individual responses and organisational support mechanisms to identify best practices for managing incivility.

Method: A mixed-methods approach was employed, involving a survey of 192 veterinary professionals from various roles and practice types. The survey measured experiences of incivility, individual factors (anxiety, stress, burnout, job satisfaction and turnover intention) and organisational factors (perceived organisational support, social support and civility climate).