Publications by authors named "L L Muldoon"
Background: Leadership styles, beliefs, and behaviours are an important and critical component to the delivery of quality care in any primary care organisation. The human resource crisis in health care has resulted in greater investments in team-based care; however, some leaders may not have experience working in team-based settings.
Aim: To explore what leadership characteristics, styles, and behaviours were most conducive to employee satisfaction, motivation, and delivery of care in a team-based primary care setting.
Article Synopsis
- The study compares the effectiveness of two contrast agents, Gadolinium (GBCA) and Ferumoxytol (FBCA), in enhancing MRI images for high-grade glioma at different field strengths (3T and 7T).
- It involved 10 patients, where lesions received both GBCA on the first day and varying doses of FBCA on the second day; CNR and nCBV were analyzed for different types of lesions.
- Results showed GBCA provided higher contrast-to-noise ratio (CNR) than FBCA at 7T, but both agents had similar performances at 3T, particularly with the higher dosage of FBCA being most effective for imaging.
Article Synopsis
- MRI with gadolinium (Gd) is commonly used to monitor glioblastoma treatment but lacks specificity in revealing the tumor's immune environment; ferumoxytol (Fe), an iron nanoparticle, targets macrophages and microglia within glioblastomas.
- In a study involving stereotactic biopsy samples and RNA microarray analysis, researchers examined how different MRI contrast agents (Gd versus Fe) correlated with immune pathways and gene expression patterns in glioblastoma patients.
- Findings indicated that Fe-enhanced imaging provided a better understanding of immune processes, showing higher levels of immune-related gene sets and M2 polarized macrophages, highlighting its potential to inform treatment and tumor biology more effectively than standard Gd-based imaging.
Article Synopsis
- Poor clinical outcomes in glioblastoma patients may result from issues within the tumor's immune environment; understanding this could lead to better patient assessment through imaging techniques.
- The study involved patients with newly diagnosed glioblastoma who underwent MRI and tissue sampling to analyze gene expression and identify different immune signatures associated with specific MRI features.
- Results showed that different MRI phenotypes correlate with varying immune responses, with enhancing lesions reflecting a stronger immune signature compared to non-enhancing areas, indicating that MRI can be a valuable tool for assessing glioblastoma's immune microenvironment.
As part of its social accountability mission, the University of Ottawa Faculty of Medicine invited community service learning (CSL) partner organizations to a guided, virtual conversation on April 12, 2021 to contribute to the future strategic directions for our curriculum. Representatives of 15 organizations participated and provided insights into how they perceive CSL students, the Faculty of Medicine, and the process of assessment. This workshop forged stronger bonds between the university and these community organizations and led to recommendations for their greater involvement going forward, an approach that could be considered by other Faculties of Medicine.
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