Publications by authors named "L L McCormick"
Established in 2021, the Alabama Regional Center for Infection Prevention and Control (ARC IPC) aims to address critical gaps in infection prevention and control (IPC) across Alabama's public health and healthcare systems. Through a comprehensive needs assessment, the Center identified priority areas which informed its targeted training and technical assistance programs. This paper examines the Center's multifaceted approach to addressing significant IPC challenges throughout the state, with particular emphasis on underserved areas.
View Article and Find Full Text PDFAim: Long QT syndrome (LQTS) and catecholaminergic polymorphism ventricular tachycardia (CPVT) are inherited cardiac disorders often caused by mutations in ion channels. These arrhythmia syndromes have recently been associated with calmodulin (CaM) variants. Here, we investigate the impact of the arrhythmogenic variants D131E and Q135P on CaM's structure-function relationship.
View Article and Find Full Text PDFObjective: To evaluate avian patients presented to a wildlife rehabilitation facility with confirmed lead toxicity for clinical signs associated with blood lead level groups, efficacy of subcutaneous chelation therapy with calcium disodium EDTA, and case outcome based on presenting blood lead levels.
Methods: A retrospective record review of 95 avian cases representing 19 species treated for lead toxicosis from a wildlife rehabilitation center in Wisconsin between 2014 and 2023 was conducted. Data were evaluated for presenting complaints, clinical signs, radiographic findings, chelation therapy protocol, clinical pathology data, and case outcome.
Article Synopsis
- Insertions and deletions (InDels) are key factors in how viruses, especially RNA viruses, evolve and develop new traits, influencing their interactions with hosts.
- This study examines the mutational tolerance of the Enterovirus A71 proteome by performing extensive tests on around 45,000 InDels, 6,000 deletions, and 41,000 amino acid substitutions.
- Findings indicate that most InDels are harmful to the virus, with only a few specific sites tolerated, which are linked to crucial functions like host recognition and immune response.
Background: After the risk of drug-induced liver injury was detected during tolvaptan clinical development for the treatment of autosomal dominant polycystic kidney disease (ADPKD), a post-marketing pharmacovigilance study was required for European Union regulatory approval.
Methods: This is an interim analysis from a prospective, observational study enrolling patients prescribed tolvaptan for ADPKD in routine clinical practice. Data were obtained through physician records collected during regular care.