Publications by authors named "L L Massarenti"
Background: The JAK2V617F mutation is a driver of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) and is also implicated in cardiovascular diseases. Thrombosis in MPN involves JAK2V617F-associated platelet activation and endothelial dysfunction, all potentially influenced by chronic inflammation. Whether the mutation affects thromboinflammatory markers similarly in non-MPN patients remains unclear.
View Article and Find Full Text PDFBackground: Gingivitis in response to biofilm formation may exhibit different trajectories. The purposes of the present study were to characterize the composition of the supragingival microbiota and salivary cytokine and protein levels in healthy individuals with different gingivitis patterns, to test the hypothesis that manifestations of gingivitis associate with specific profiles in terms of supragingival microbiota, salivary cytokines, and proteins.
Methods: Forty orally and systemically healthy individuals refrained from all oral hygiene procedures for a period of 14 days, followed by a resolution period of 14 days with regular oral care.
Article Synopsis
- Periodontitis is an inflammatory disease linked to certain bacteria, and this study explores how the immune response of T-cells is affected in patients with varying grades of the disease.
- The researchers compared immune responses in patients with grade B and C periodontitis to healthy controls by analyzing cytokine production after exposure to specific bacteria.
- Findings indicate that patients with higher grades of periodontitis demonstrate significantly altered T-cell responses, including lower levels of regulatory T-cells and higher levels of proinflammatory cytokines, suggesting a relationship between immune responses and disease severity.
Background: Increasing evidence indicates that periodontitis contributes to systemic low-grade inflammation. Porphyromonas gingivalis is strongly associated with periodontitis, and antibodies against the bacterium may be used as a serological proxy to account for periodontal status, when studying diseases associated with periodontitis. The aim of the present study is to identify an easily accessible and reliable serological biomarker for determination of periodontal status and oral carriage of the bacterium.
View Article and Find Full Text PDFArticle Synopsis
- LL37, a DNA-binding peptide associated with psoriasis, may act as an autoantigen found in neutrophil extracellular traps (NETs) and is suspected to have increased immunogenicity when citrullinated (citLL37).
- The study aimed to assess how B and T cells respond to both native and citLL37 forms of LL37, and to analyze the prevalence of circulating NETs in psoriasis patients compared to healthy donors.
- Results showed that citLL37 triggers immune responses in psoriasis patients, with a significant portion exhibiting increased cytokine production, and identified two distinct patient groups based on their cytokine response patterns and presence of circulating NETs.