Publications by authors named "L L Malone"
To determine the clinical utility of teleneuropsychology (teleNP) services in screening for cognitive concerns in a population of children and adolescents presenting with long COVID. This cross-sectional study evaluated 76 pediatric patients (64% female, = 13.48, = 2.
View Article and Find Full Text PDFAnomalous coronary arteries are associated with sudden cardiac death, although only in a relatively small percentage. Although this has been a field of study for years and there are many ongoing studies of larger patient cohorts and longer term follow-up, important questions remain at present in clinical decision-making, particularly whether or not to have surgery. Advanced imaging techniques including coronary computed tomography (CT) and cardiac magnetic resonance (MR) play an important role in the workup of patients with known or suspected anomalies including delineating origin and course as well as defining presence of high-risk imaging features.
View Article and Find Full Text PDFThe Chimalliviridae family of bacteriophages (phages) form a proteinaceous nucleus-like structure during infection of their bacterial hosts. This phage 'nucleus' compartmentalises phage DNA replication and transcription, and shields the phage genome from DNA-targeting defence systems such as CRISPR-Cas and restriction-modification. Their insensitivity to DNA-targeting defences makes nucleus-forming jumbo phages attractive for phage therapy.
View Article and Find Full Text PDFBackground: Little is known about quality of life, sleep, and mental health in children with moyamoya arteriopathy (MMA). A better understanding of patient-reported outcomes may lead to improved treatment.
Methods: Patients with MMA <26 years old and their caretakers completed validated, age-appropriate questionnaires including the Pediatric Quality of Life (PedsQL) Inventory and Patient-Reported Outcomes Measurement Information System (PROMIS) measuring health-related quality of life, sleep, anxiety, depression, and overall health.
Article Synopsis
- - Glomerulopathy leads to damage in the filtration barrier of the kidneys, often resulting in nephrotic syndrome (NS), which currently has limited treatment options primarily involving steroids with mixed effectiveness.
- - A 7-year-old boy with a history of NS underwent genetic testing and biopsy, revealing abnormal changes, and after an initial steroid response, he was treated with anakinra and adalimumab, achieving remission without treatment for the past year.
- - The case highlights the interplay of genetic and environmental factors in glomerular diseases and suggests that early intervention with biologic treatments may promote kidney recovery and reduce the need for steroids, indicating a need for further research.