Publications by authors named "L L M Sampaio"
Myelodysplastic Neoplasm (MDS) is a cancer associated with aging, often leading to acute myeloid leukemia (AML). One of its hallmarks is hypermethylation, particularly in genes responsible for DNA repair. This study aimed to evaluate the methylation and mutation status of DNA repair genes (single-strand - XPA, XPC, XPG, CSA, CSB and double-strand - ATM, BRCA1, BRCA2, LIG4, RAD51) in MDS across three patient cohorts (Cohort A-56, Cohort B-100, Cohort C-76), using methods like pyrosequencing, real-time PCR, immunohistochemistry, and mutation screening.
View Article and Find Full Text PDFComparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. Controlled and randomized clinical trial.
Arch Med Sci
May 2024
Introduction: This study aimed to compare the effectiveness of two methods for non-invasive mechanical ventilation in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - using a helmet interface with a flow meter and positive end-expiratory pressure valve versus a traditional mechanical ventilator.
Material And Methods: We conducted a single-center randomized clinical trial involving 100 adult SARS-CoV-2 patients in a specialized private hospital. Participants were randomly assigned to two groups: one using the helmet interface with a flow meter and positive end-expiratory pressure valve and the other employing conventional mechanical ventilation.
Article Synopsis
- Despite improvements in reducing maternal mortality worldwide, significant challenges remain, particularly in low- and middle-income countries.
- Effective strategies to lower maternal mortality need a combination of health policy implementation and social development.
- Primary care is crucial for recognizing risk factors and early signs of maternal health issues, while antenatal care addresses various conditions that can improve maternal outcomes.
Purpose: The described evolution in prenatal and postnatal periods appears to support the hypothesis that the torcular pseudomass (TP) is probably a physiological, highly frequent and transient developmental finding. Neverthless, it remains to be determined whether TP has any relation with the final anatomy of the adjacent venous sinuses or any anatomic variants. We aimed to explore the relation of the TP with the adjacent dural venous anatomy/anatomic variants in the prenatal period, using MR angiography (2D TOF MRA).
View Article and Find Full Text PDFArticle Synopsis
- - The COVID-19 pandemic significantly disrupted pulmonary rehabilitation (PR), necessitating changes in how it is delivered to ensure patient care and outcomes are maintained.
- - A review of studies from various medical databases revealed that multidisciplinary and individualized rehabilitation programs, including telerehabilitation, have shown promise, but many patients still face barriers to access.
- - Despite effective treatment options, the uptake of PR remains low globally, especially in low-income countries where technological limitations hinder service delivery.