Publications by authors named "L L Lau"
Background: Modern sedentary lifestyles are prevalent among individuals with osteoarthritis. However, direct evidence linking such behaviours as causative factors of osteoarthritis remain limited due to the presence of confounding variables.
Objective: This study aims to determine the extent to which lifestyle factors have causal effects on osteoarthritis through a two-sample Mendelian randomisation (MR) study.
Marine fish farming served as a sustainable alternative to capture fisheries. However, it faced challenges such as disease management, water quality maintenance, and minimizing environmental impacts. Among these challenges, fungal infections are particularly concerning.
View Article and Find Full Text PDFObjective: Despite advancements in pharmacological treatments, living with inflammatory arthritis (IA) (including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA)) can make it challenging to engage in social activities, which may increase the risk of loneliness. Although loneliness is predominantly prevalent in IA, its origin and impact on mental health status on daily life with IA remain unexplored. Therefore, the objective of this study was to describe the experiences of people with IA in relation to loneliness.
View Article and Find Full Text PDFUnlabelled: Mild hypoxic-ischemic encephalopathy is common in neonates with no evidence-based therapies, and 30-40% of patients experience adverse outcomes. The nature and progression of mild injury is poorly understood. Thus, we studied the evolution of mild perinatal brain injury using longitudinal two-photon imaging of transgenic fluorescent proteins as a novel readout of neuronal viability and activity at cellular resolution.
View Article and Find Full Text PDFArticle Synopsis
- Comprehensive Geriatric Assessment (CGA) is crucial for older patient care but is often impractical in primary settings due to its length; a shorter assessment could serve as an effective alternative.
- A scoping review analyzed 25 studies on brief geriatric assessments used in community and primary care, focusing on four main domains: physical health, functional status, mobility/balance, and psychological health; most assessments were self-reported questionnaires.
- While brief assessments can identify older adults with higher needs, studies showed limited improvement in health outcomes when integrated with clinical interventions, highlighting the need for clearer questions to enhance feasibility for self-administration.