Publications by authors named "L L Latta"
This study describes a complex human in vitro model for evaluating anti-inflammatory drug response in the alveoli that may contribute to the reduction of animal testing in the pre-clinical stage of drug development. The model is based on the human alveolar epithelial cell line Arlo co-cultured with macrophages differentiated from the THP-1 cell line, creating a physiological biological microenvironment. To mimic the three-dimensional architecture and dynamic expansion and relaxation of the air-blood-barrier, they are grown on a stretchable microphysiological lung-on-chip.
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- Bacterial biofilms act as protective barriers, making it difficult for antibiotics to work effectively, but introducing oxygen can improve their effectiveness.
- This study investigates the use of oxygen-producing calcium peroxide nanoparticles (CaO NP) combined with tobramycin sulfate (Tob) on Pseudomonas aeruginosa biofilms, showing that the combination significantly enhances biofilm eradication compared to using Tob alone.
- In natural biofilms from human mouths, CaO NP increased the percentage of dead bacteria, and when combined with Tob, the dead bacteria percentage rose even further, demonstrating its potential benefits in real-life applications.
Pseudomonas aeruginosa (PA) is a major healthcare concern due to its tolerance to antibiotics when enclosed in biofilms. Tobramycin (Tob), an effective cationic aminoglycoside antibiotic against planktonic PA, loses potency within PA biofilms due to hindered diffusion caused by interactions with anionic biofilm components. Loading Tob into nano-carriers can enhance its biofilm efficacy by shielding its charge.
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- Odontoid fractures, especially common in the elderly, lead to serious health risks, and surgical treatment shows better outcomes than non-surgical methods.
- This study investigates the stability of Type II odontoid fractures after certain surgical fixations (Magerl and Harms) using a biomechanical approach with cadaver specimens.
- Results indicate both fixation techniques maintain similar movement patterns in the cervical spine during various types of motion, with no significant differences in stability or movement dynamics between the two methods.
Purpose: Aniridia is a rare corneal disease that is often associated with aniridia-associated keratopathy (AAK). In AAK, the conjunctival tissue crosses the limbal border, forming a corneal pannus that extends into the corneal center. With increasing AAK severity, corneal pannus formation, vascularization, and ocular surface inflammation increase.
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