Clinical trial of bumetanide versus furosemide in patients with congestive heart failure.

A clinical trial was conducted in open, randomized, parallel fashion to determine the effectiveness and safety of bumetanide compared with those of furosemide in 42 outpatients with edema due to congestive heart failure. All patients were free from any significant hepatic or renal disease. The duration of the study was six months, except for 12 patients who were continued under treatment with bumetanide for an additional six months.

Great vessel, cardiac chamber, and wall growth patterns in normal children.

The purpose of this study was to establish normal echocardiographic measurements of valvular motion, cavity dimensions, great vessel diameters, and right, left and septal wall thicknesses of children ranging in size from infants to full growth. The study group was composed of 205 normal, healthy children for whom echocardiograms and subsequent measurements were performed in a standardized manner. The following measurements were performed: left ventricular end-diastolic and end-systolic dimension, right ventricular end-diastolic cavity dimension, right ventricular end-diastolic anterior wall thickness, left ventricular end-diastolic posterior wall thickness, ventricular septal end-diastolic thickness, maximal left atrail dimension, end-diastolic aortic and pulmonary artery diameter, end-diastolic cardiac and septal depth, maximal aortic leaflet separation, and maximal anterior mitral and anterior tricupsid amplitude.