A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model.

Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic deterioration. To address this, a dual latex balloon catheter was designed for temporary closure and tested in a pig model.

MOLGAECL: Molecular Graph Contrastive Learning via Graph Auto-Encoder Pretraining and Fine-Tuning Based on Drug-Drug Interaction Prediction.

Drug-drug interactions influence drug efficacy and patient prognosis, providing substantial research value. Some existing methods struggle with the challenges posed by sparse networks or lack the capability to integrate data from multiple sources. In this study, we propose MOLGAECL, a novel approach based on graph autoencoder pretraining and molecular graph contrastive learning.

From interference to insight: pseudo-lipidemia led to the diagnosis of Waldenström macroglobulinemia.

Waldenström macroglobulinemia (WM) is a rare hematological disorder with an annual incidence of about 3 per million. Its clinical manifestations are diverse and non - specific, and approximately 30% of patients are asymptomatic, making early diagnosis challenging. This paper reports a 73-year-old female who was admitted to the hospital due to atrial fibrillation.

Fabrication of a Whitlockite/PLGA Scaffold with Hierarchical Porosity for Bone Repair.

Regenerating functional bone tissue in critical-sized defects remains a formidable issue. Bone-tissue engineering (BTE) scaffolds are emerging as potential alternatives to bone transplantation for the repair of bone defects. However, developing BTE scaffolds with unique bone-healing properties and natural bone porous structure is challenging.