Publications by authors named "L L Goodwin"
Introduction: Unplanned out-of-hospital births (UOHBs) are associated with poorer outcomes for babies, especially those born prematurely. The current Newborn Life Support (NLS) course offered by Resuscitation Council UK (RCUK) is not designed to address the challenges associated with birth out of hospital. A new course was developed to address these challenges.
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- The bioanalytical community traditionally uses blank matrices from preclinical animals for method validation, as required by guidelines, but this practice is increasingly being questioned.
- Despite scientific support for using surrogate matrices instead, regulatory bodies remain hesitant to accept them for most cases, only allowing them for rare situations.
- The European Bioanalysis Forum is advocating for the broader acceptance of surrogate matrices, emphasizing ethical considerations and the need for continued discussions, backed by new experimental data.
Article Synopsis
- The International Mouse Phenotyping Consortium (IMPC) creates and studies mouse lines with specific gene mutations to better understand gene functions, using advanced techniques such as the Cas9 nuclease for enhanced efficiency.
- The IMPC has produced 3313 knockout mouse lines, allowing for a comprehensive analysis of factors that influence successful gene editing in living organisms.
- The research highlights that the essentiality of genes significantly affects the success rates in producing null alleles, and offers best practice guidelines for using Cas9 in gene engineering linked to human diseases.
Sophisticated tools such as computer vision techniques in combination with 1D lineout type analyses have been used in automating the analysis of spectral data for high energy density (HED) plasmas. Standardized automation can solve the problems posed by the complexity of HED spectra and the quantity of data. We present a spectroscopic code written for automated and streamlined analysis of spatially resolved x-ray absorption data from the COAX platform on Omega-60.
View Article and Find Full Text PDFIntroduction: Current clinical guidelines recommend that patients with co-occurring psychosis and alcohol or substance use disorders (A/SUD) receive evidenced-based treatment for both disorders, including psychological intervention for psychosis. However, the efficacy of such treatments for individuals with co-occurring psychosis and A/SUD is unclear.
Study Design: Randomized controlled trials (RCTs) of psychological interventions for psychosis were systematically reviewed, to investigate how alcohol and substance use has been accounted for across sample inclusion and secondary measures.