[The effect of alpha-adrenoblockaders on the lipid complex of the myocardium, liver and erythrocytes in dogs with pulmonary heart failure].

Fatty acid spectrum of phospholipids and free cholesterol level in the myocardium, liver and erythrocytes were studied in dogs with the experimental lung-heart insufficiency (LHI). The content of polyunsaturated fatty acids of phospholipids in erythrocytes from peripheric blood and in free cholesterol level (2-3 times) in myocardium, liver and erythrocytes of dogs under investigated conditions decreased. It is shown that pharmacotherapy with alpha-adrenoblockers (thropaphen and prasozin) has led to the normalization of disturbances of the erythrocytic lipid complex and had caused inhibition of peroxidase reactions in the myocardium and liver of the dogs with LHI.

[The effect of mildronate on erythrocyte membrane permeability in experimental lung pathology].

With the use of the erythrocyte osmotic and acidic resistance methods, the experiments on intact albino rats by applying a model of chronic non-specific lung diseases and those in vitro have shown that mildronate has a membrane-stabilizing action only when given in high doses (500 mg/kg) and concentrations (10(-3)-10(-4) M). When used in low doses (5, 25, 50, and 200 mg/kg) and concentrations (10(-5)-10(-7) M), in produces no positive effect.

[Tropaphen in experimental drug therapy of cor pulmonale].

The influence of alpha-adrenoblocking drug tropaphen on cardio- and haemodynamics under experimental lung-heart failure was studied in dogs. The findings suggest effectiveness of tropaphen administration in such pathology shown by a decrease of lung hypertension and heart overload, significant increase of the contractile activity and relaxation properties of myocardium of both ventricles and in cardiac pump function optimization.

[The role of prazosin in regulating cardio- and hemodynamics in the early stage of experimental lung-heart failure].

Canine experiments have shown that prazosin used in the course of therapy for pulmonary hypertension and abolition of heart overload substantially enhanced myocardial contractility and relaxing properties of the both ventricles and improved cardiac pump function.