Brine shrimp Artemia salina to evaluate the impact of environmental concentrations of BMAA and isomers, DAB and AEG, via mortality (nauplii) and behavioural (adult) tests.

BMAA and its isomers, DAB and AEG, are toxins mainly produced by cyanobacterial blooms and represent an emerging risk worldwide. Anthropization and climate changes are expanding blooms and the presence of these toxins has been evidenced in different environments including water and air. Investigated since decades, BMAA is a recognized danger in cases of bioaccumulation or when directly exposed to relatively high doses (μg/L).

International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

Importance: A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.

Objective: To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.

Highlights of the updated Dutch evidence- and consensus-based guideline on psoriasis 2017.

 https://doi.org/10.1111/bjd.

Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial: a critical appraisal.

Aim: Arits et al. aimed to assess whether the effectiveness of imiquimod and fluorouracil is not inferior to methyl aminolaevulinic acid (MAL) photodynamic therapy (PDT) in patients with superficial basal cell carcinoma.

Setting And Design: This single-blind, noninferiority, randomized controlled trial was conducted at one coordinating academic hospital and six peripheral dermatological departments in the Netherlands between March 2008 and August 2010.