Publications by authors named "L Kuthanova"

We study the interaction of microplasma with viscous liquid in a narrow gap. The reduced surface tension and viscosity of the liquid droplet from local plasma-heating induce a radial fingering. The introduced methodology enables spatially and temporally resolved quantification of dissipated power density and of resulting velocity of the advancing plasma-liquid interface.

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End-stage renal disease (ESRD) is a serious health problem worldwide. The high prevalence of cardiovascular diseases and chronic inflammation remains a major cause of morbidity and mortality in haemodialysed patients. Beside some external factors, genetic predisposition both to renal failure and poor prognosis has been assumed.

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The dysbalance in the expression of proinflammatory and anti-inflammatory cytokines, which is partially genetically determined, might have essential impact on the clinical outcome and survival of haemodialysed (HD) patients. A total of 500 HD patients and 500 healthy controls were genotyped for three single-nucleotide polymorphisms (SNPs: TNFA -308G/A, IL10 -1082G/A, IFNG +874A/T). To detect the SNPs' impact on clinical outcome and survival, the HD population was divided into two subgroups depending on the length of HD therapy.

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Heritability studies have estimated the genetically attributable part of body mass index variance to be in the range of 30-70 %. Rs7566650 (G>C) single-nucleotide polymorphism (SNP) near the promoter of the INSIG2 gene has been identified as associated with body mass index. The gene product of INSIG2 is involved in regulation of fatty acid and cholesterol synthesis.

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Article Synopsis
  • The study explores how chronic low oxygen levels (hypoxia) impact gene expression in the heart, focusing on differences between the right and left ventricles.
  • Researchers found significant changes in gene expression primarily in the right ventricle of hypoxic male and female mice, with a single change noted in the left ventricle of hypoxic males.
  • The findings highlight the critical role of the HIF1a protein in these adaptations and suggest that there are notable differences in how male and female hearts respond to hypoxia, underscoring the need for gender-specific approaches in medical treatments.
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