Publications by authors named "L Kurch"
Importance: The current standard-of-care salvage therapy in relapsed/refractory classic Hodgkin lymphoma (cHL) includes consolidation high-dose chemotherapy (HDCT)/autologous stem cell transplant (aSCT).
Objective: To investigate whether presalvage risk factors and fludeoxyglucose-18 (FDG) positron emission tomography (PET) response to reinduction chemotherapy can guide escalation or de-escalation between HDCT/aSCT or transplant-free consolidation with radiotherapy to minimize toxic effects while maintaining high cure rates.
Design, Setting, And Participants: EuroNet-PHL-R1 was a nonrandomized clinical trial that enrolled patients younger than 18 years with first relapsed/refractory cHL across 68 sites in 13 countries in Europe between January 2007 and January 2013.
Article Synopsis
- The study aimed to validate a deep learning model for predicting treatment outcomes in diffuse large B-cell lymphoma patients across 5 clinical trials, comparing it to the international prognostic index (IPI) and radiomic models.
- The deep learning model, trained on PET/CT scans, demonstrated a higher predictive performance (AUC of 0.66) than IPI (AUC of 0.60) and performed well across all trials.
- While the deep learning and clinical PET models showed similar performance (AUC of 0.69), the PET model achieved the highest AUC (0.71), although the deep learning model provided outcomes without requiring tumor delineation.
Article Synopsis
- Hodgkin lymphoma involving the central nervous system (CNS) is very rare, with a reported incidence of 0.9% in a study of nearly 5,000 pediatric patients.
- Most cases had single lesions in areas like the thoracic and lumbar spine, which originated from nearby soft tissue or bone rather than directly in the CNS parenchyma.
- After two cycles of chemotherapy, a significant majority of lesions showed complete metabolic response, and while some lesions were treated with radiation, relapses were minimal, highlighting the importance of surrounding tissues in the management of CNS involvement.
Article Synopsis
- Hypodense volumes (HDV) in mediastinal masses were identified in 29.7% of Hodgkin lymphoma patients analyzed from a study involving 1178 staging CT scans.
- These HDVs were predominantly found in larger tumor volumes and exhibited various patterns, including single lesions in 69.4% of cases and well delineated lesions in 70.1% of cases.
- Patients with HDV displayed more severe symptoms and had a lower 5-year progression-free survival rate (79.6% for HDV > 40 ml) compared to those with lower HDV levels, indicating a potential connection between HDV presence and poorer prognosis in Hodgkin lymphoma.