Publications by authors named "L Kujovska Krcmova"
Coagulation in familial hypercholesterolemic patients: effect of current hypolipidemic treatment and anticoagulants.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Familial hypercholesterolemia (FH) is a relatively rare genetic disease associated with high serum cholesterol levels but also with abnormalities in blood coagulation. Novel pharmacotherapeutic approaches in FH including proprotein convertase subtilisin/kexin type 9 antibodies (PCSK9Ab) are very efficient in decreasing cholesterol levels but their impact on coagulation in FH is not yet established. Therefore, we hypothesized that these novel antidyslipidemic drugs can positively impact blood coagulation due to their more potent effect on cholesterol.
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- Vitamin B, specifically cobalamin, is essential for human health as it plays key roles in converting l-methylmalonyl coenzyme A to succinyl coenzyme A and in forming methionine from homocysteine.
- Unlike prokaryotes, eukaryotes like animals and plants cannot synthesize vitamin B, so humans need to obtain it from dietary sources such as meat, dairy, fish, and eggs, putting vegetarians at risk for deficiency.
- This review covers the biological aspects of vitamin B, its functions, causes and symptoms of deficiency, diagnostic methods, prevention and treatment approaches, as well as its pharmacological applications and potential toxicity.
Objectives: Concentrations of neopterin, kynurenine and kynurenine/tryptophan ratios predict prognosis and the need for oxygen therapy in patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aims of the present study were to evaluate the changes of these biomarkers early in the course of infection, the association with the prior coronavirus disease (COVID-19) vaccination and therapeutic administration of Anti-SARS-CoV-2 monoclonal antibodies, investigation of other potential biomarkers including neuropilin, 8-hydroxy-2-deoxyguanosine and 8-hydroxyguanosine in patients hospitalized with SARS-CoV-2 infection and an assessment of these biomarkers and vitamins A, E and D in patients with post-COVID syndrome.
Methods: Urine and blood samples were obtained on the 1st to the 4th day and 4th to 7th day from 108 patients hospitalized with COVID-19.
Objectives: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder caused by increased platelet destruction and altered production. Despite the well-described pathophysiological background of immune dysregulation, current treatment guidelines consist of monotherapy with different drugs, with no tool to predict which patient is more suitable for each therapeutic modality.
Methods: In our study, we attempted to determine differences in the immune setting, comparing the patients' responses to administered therapy.
Head-to-head ex vivo comparison of clinically used direct anticoagulant drugs.
Naunyn Schmiedebergs Arch Pharmacol
June 2024
Article Synopsis
- - The study investigates the effectiveness of four novel anticoagulants—dabigatran, argatroban, rivaroxaban, and apixaban—by comparing their coagulation responses in blood samples from 50 healthy donors.
- - Results showed rivaroxaban was most effective in prolonging prothrombin time (PT/INR), while argatroban was best for activated partial thromboplastin time (aPTT).
- - The study found that higher body mass index (BMI) was linked to a reduced effect of the anticoagulants, and higher cholesterol and triglyceride levels affected aPTT, indicating the need for individualized treatment based on these factors.