Publications by authors named "L Kucerova"
The aberrant activation of the hepatocyte growth factor receptor (c-Met) in malignant melanoma is associated with poor prognosis, fostering tumor progression, angiogenesis, and invasiveness. While therapeutic targeting of this pathway has shown promise in several tumors, our previous findings revealed increased tumorigenicity following tyrosine kinase inhibitor SU11274 treatment. Therefore, we hypothesized that administering c-Met inhibitors may elicit distinct effects in human melanoma cells.
View Article and Find Full Text PDFThe failure of bonded composite materials is accompanied by specific failure modes. These are specifically Mode I, Mode II, Mode III, and their combination (so-called mixed mode). These modes depend on the direction and type of loading.
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- * A study involving 207 newly diagnosed GCT patients linked higher expression levels of GSTM1 to poorer treatment outcomes, particularly in terms of relapse-free survival, especially in tumor types like seminoma and choriocarcinoma.
- * The findings indicate that GSTM1 levels are a potential indicator of treatment resistance in GCTs and may help predict patient outcomes independently of other established risk factors.
Article Synopsis
- This review advocates for using FDA-approved antibody-drug conjugates (ADCs) as a treatment option for recurring germ cell tumors (GCTs), similar to their use in other solid tumors resistant to chemotherapy.
- Germ cell tumors primarily affect the testes and ovaries and are the most common cancer in young men; although initially responsive to cisplatin chemotherapy, many patients develop resistance, leading to recurrence.
- ADCs combine targeted antibodies with chemotherapy drugs, providing a new way to attack GCTs by specifically targeting cancer antigens, making them potentially effective for patients with relapsed testicular GCTs resistant to conventional treatments.
Breast cancer metastases are the main reason for women´s highest cancer mortality. Even though tumor cell dissemination via circulating tumor cells (CTC) released from the primary site is a very ineffective process, distant metastases appear in 46% of triple-negative breast cancer (TNBC) patients corresponding to the disease aggressiveness. Laboratory models for functional testing which mimic the spread of metastatic cells are needed for efficient investigation of the underlying mechanisms and therapeutic intervention.
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