Publications by authors named "L Krishna Kumari"
Background: There is a paucity of literature regarding the effect of anesthetic techniques on anti-tumor immunity, especially in Oral cavity Malignancies. We designed a study to evaluate the effect of 3 anesthetic techniques - Opioid, Lignocaine infusion and Dexmeditomedine infusion-based on anti-tumor immunity, using TGF-β, T-helper cell profile and inflammatory markers such as IL-6 and IL-10.
Methods: A pilot prospective randomized trial was conducted in 90 patients undergoing surgery for Oral cavity malignancy under general anesthesia in a tertiary specialty cancer hospital.
Micronuclei (MN), defined as small extra-nuclear chromatin bodies enclosed by a nuclear envelope, serve as noticeable markers of chromosomal instability (CIN). The MN have been used for breast cancer (BC) screening, diagnosis, and prognosis. However, more recently they have gained attention as seats for active chromosomal rearrangements.
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- There is limited research on how different anesthetic techniques impact antitumor immunity in gall bladder cancer patients, leading to a study comparing propofol-based total intravenous anesthesia with sevoflurane-based general anesthesia.
- A pilot trial involving 64 patients revealed that propofol raised serum levels of tumor growth factor-β (TGF-β), while sevoflurane increased levels of interleukin-17A, indicating a shift toward TH17 cell activity.
- The study suggests that the choice of anesthesia may influence immune responses in gall bladder cancer patients, but further extensive research is needed to validate these findings.
Candida auris has emerged as a major multidrug-resistant nosocomial pathogen. The organism exhibits a persistent colonising phenotype, and causes recalcitrant infections often strongly linked to biofilm formation. Alternate strategies are urgently needed to combat this yeast and its biofilm-associated phenotype.
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- The study presents a case series of 49 patients who underwent minimally invasive tubular surgery for spinal schwannomas and neurofibromas, highlighting the procedure’s effectiveness and safety.
- The authors review existing literature on similar cases, providing insights into surgical outcomes and patient recovery following the procedure.
- The article emphasizes the potential benefits of minimally invasive techniques over traditional surgeries, such as reduced recovery time and lower complication rates.